English: Differences in cysteine and serineproteolysismechanisms.
The protease (black) performs a nucleophilic attack on peptide substrate (red) to form a tetrahedral intermediate. This breaks down by ejection of the first product, the substrate C-terminus, to form the acyl-enzyme intermediate. Water replaces the first product and hydrolysis occurs via a second tetrahedral intermediate to regenerate free enzyme. Indicated differences are (a) the deprotonated cysteine, (b) aspartate (grey) not present in all cysteine proteases, (c) concerted deprotonation of serine, (d) aspartate hydrogen bonding, (e) amide protonation of the first leaving group, (f) alcohol protonation of the serine leaving group.
des Wärch an anderi wytergee – des Wärch kopiere, verbreite un ibertrage
des Wärch verändere – des Wärch aapasse
Unter däne Bedingige:
Namenännig – Du muesch aagmässeni Aagabe zum Urheber un dr Rächt mache, e Link zue dr Lizänz zuefiege un aagee, eb Änderige gmacht wore sin. Die Aagabe chenne in ere aagmässene Art gmacht wäre, aber nit eso, ass dr Yydruck entstoht, ass dr Lizänzgeber Dii oder Dyy Gebruch vum Wärch unterstitze un guetheiße.
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