English: A comparison of the two mechanisms used for proteolysis. enzyme is shown in black, substrate protein in red and water in blue.The top panel shows 1-step hydrolysis where the enzyme uses an acid to polarise water which then hydrolyses the substrate. The bottom panel shows 2-step hydrolysis where a residue within the enzyme is activated to act as a nucleophile (Nu) and attack the substrate. This forms an intermediate where the enzyme is covalently linked to the N-terminal half of the substrate. In a second step, water is activated to hydrolyse this intermediate and complete catalysis. Other enzyme residues (not shown) donate and accept hydrogens and electrostatically stabilise charge build-up along the reaction mechanism.
des Wärch an anderi wytergee – des Wärch kopiere, verbreite un ibertrage
des Wärch verändere – des Wärch aapasse
Unter däne Bedingige:
Namenännig – Du muesch aagmässeni Aagabe zum Urheber un dr Rächt mache, e Link zue dr Lizänz zuefiege un aagee, eb Änderige gmacht wore sin. Die Aagabe chenne in ere aagmässene Art gmacht wäre, aber nit eso, ass dr Yydruck entstoht, ass dr Lizänzgeber Dii oder Dyy Gebruch vum Wärch unterstitze un guetheiße.
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